Adipocyte-Derived Adipokines and Other Obesity-Associated Molecules in Feline Mammary Cancer

Obesity has been identified as a serious health concern in domestic cats. Feline mammary cancer (FMC) is also concern, it highly prevalent and aggressive. Considering the connection between obesity breast cancer, worthwhile to investigate potential obesity–cancer relationship FMC. This review investigated association adipokines other obesity-associated molecules FMC, with aim of identifying gaps current literature for future research. Based on reports date, was found that tissue concentrations leptin, serum leptin receptor, amyloid A, estrogen correlate positively negatively The roles adiponectin prolactin FMC development were investigated, but are either lacking or insufficient suggest an association. Numerous research could be used opportunities These include need studies additional cohorts confirm leptin/leptin receptor A address role It important genetic determinants evaluate use molecular-targeted therapies exploit enrichment triple-negative immunophenotype clinical needs both human Finally, mechanistic any reviewed scarce generate hypotheses ultimately advance our knowledge outcome